This is a good overview of factors which should influence your choice of a homestead location. Assuming you get to choose your location.
https://survivalblog.com/homestead-design-practical-tactical-agricultural-survival-perspective-c-f/It doesn't go into great detail, but does cover many topics which will help you decide on a suitable area. The assumption is that you expect to be as close to self-sufficient as possible (think pioneers in the US West).
If your plans include access to a commercial network of stores and businesses, then you are dependent on that network and may not be prepared (that word again) for an "event" which removes that network.