Wool remains a top choice for all around clothing.
That being said, some people cannot tolerate it and have a positive aversion to even considering owning wool clothing.
This article is for those people.
https://survivalcommonsense.com/keep-wool-from-itching/For the rest of you, have some wool clothing, in addition to cotton and synthetics.
Given the choice of being cold or itching, I'd tolerate the itching... but wool doesn't bother me.